Hao Sun, Ph.D.

Hao Sun's Headshot
Assistant Professor
Chemistry Graduate Program Coordinator

Department of Chemistry and Chemical & Biomedical Engineering
Tagliatela College of Engineering
Education

Postdoctoral Fellow, Polymer Chemistry, Northwestern University
Ph.D., Organic Chemistry, University of Florida
M.Sc., Polymer Chemistry & Physics, Sun Yat-sen University
B.Sc., Chemistry, Wuhan University

About Hao

Hao is an organic and polymer chemist. He joined the faculty of the University of New Haven in August 2021. He will teach Organic Chemistry (CHEM2201) and Advanced Organic Chemistry (CHEM4501) in the fall of 2021.

Hao鈥檚 research program seeks chemistry-centered multidisciplinary approaches to addressing the challenges in global health and environment. Several areas in the intersection of synthetic polymer chemistry, materials, and biomedicine will be investigated, with particular focus on those most closely related to environmental and biomedical applications. His current research interests are centered in: (1) developing chemically-recyclable polymer materials for environmental applications; (2) developing modular and scalable approach for polymer-based delivery systems of therapeutics (e.g., gene, peptides, and proteins); (3) designing next-generation sequence-defined polymers for understanding the role of monomer sequence in governing the material properties.

Professor Sun鈥檚 research group website:

Publications

鈥 denotes the co-first author.
*denotes the corresponding author.

  1. Sun, H.鈥, Liang, Y.鈥, Thompson, M.P., Gianneschi, N.C., "Degradable Polymers via Olefin Metathesis Polymerization", Prog. Polym. Sci., 2021, 120, 101427.
  2. Scheutz, G.M., Elgoyhen, J., Bentz, K.C., Xia, Y., Sun, H., Zhao, J., Savin, D.A., Sumerlin, B.S., "Mediating Covalent Crosslinking of Single-Chain Nanoparticles through Solvophobicity in Organic Solvents", Polym. Chem., 2021, in press.
  3. Zhou, X., Gong, X., Cao, W., Forman, C.J., Oktawiec, J., D鈥 Alba, L., Sun, H., Thompson, M.P., Hu, Z., Kapoor, U., McCallum, N.C., Malliakas, C.D., Farha, O.K., Jayaraman, A., Shawkey, M.D., Gianneschi, N.C., "Anisotropic Synthetic Allomelanin Materials via Solid State Polymerization of Self-Assembled 1,8-Dihydroxynaphthalene Dimers", Angew. Chem. Int. Ed., 2021. DOI: 10.1002/anie.202103447.
  4. Hu, Z., Sun, H., Thompson, M.P., Xiao, M., Allen, M.C., Zhou, X., Ni, Q., Wang, Z., Li, W., Burkart, M.D., Deheyn, D.D., Dhinojwala, A., Shawkey, M.D., Gianneschi, N.C. "Structurally Colored Inks from Synthetic Melanin-Based Crosslinked Supraparticles", ACS Materials Lett., 2021, 3, 50鈥55.
  5. Sun, H.鈥, Cao, W.鈥, Zang, N.鈥, Clemons, T. D., Scheutz, G. M., Hu, Z., Thompson, M. P., Liang, Y., Vratsanos, M., Zhou, X., Choi, W., Sumerlin, B. S., Stupp, S. I, Gianneschi, N. C. 鈥淧roapoptotic Peptide Brush Polymer Nanoparticles via Photoinitiated Polymerization-Induced Self-Assembly.鈥 Angew. Chemie. Int. Ed. 2020, 59, 43, 19136-19142.
  6. Choi, W.; Sun, H.; Battistella, C.; Berger, O.; Vratsanos, M.A.; Wang, M.; Gianneschi, N. C., 鈥淏iomolecular densely grafted brush polymers: oligonucleotides, oligosaccharides and oligopeptides鈥, Angew. Chem. Int. Ed., 2020, 59, 45, 19762-19772.
  7. Zhu, J.; Sun, H.; Callmann, C. E.; Thompson, M. P.; Battistella, C.; Proetto, M. T.; Carlini, A.S.; Gianneschi, N. C., 鈥淧aclitaxel-terminated peptide brush polymers鈥, Chem. Commun., 2020, 56, 6778-6781.
  8. Liang, Y.; Sun, H.*; Cao, W.; Thompson, M. P.; Gianneschi, N. C.* "Degradable Polyphosphoramidate via Ring-Opening Metathesis Polymerization." ACS Macro Lett. 2020, 9, 10, 1417鈥1422.
  1. Noh, J.; Cao, W.; Sun, H.; Yang, Y.; Gianneschi, N. C.; Abbott, N., 鈥淪elf-Assembly of Macromolecules within Single Topological Defects of Nematic Solvents鈥, Chem. Mater., 2020, 32, 15, 6753鈥6764.
  2. Cao, W.; McCallum, N. C.; Ni, Q. Z.; Li W., Boyce, H.; Mao, H.; Zhou, X.; Sun, H.; Thompson, M. P.; Battistella, C.; Wasielewski, M. R.; Dhinojwala, A.; Shawkey, M. D.; Burkart, M. D.; Wang, Z.; Gianneschi, N. C., 鈥淪elenomelanin: An Abiotic Selenium Analogue of Pheomelanin鈥, J. Am. Chem. Soc. 2020, 142, 29, 12802鈥12810.
  3. Cavell, A.; Krasecki, V.; Li, G.; Sharma, A.; Sun, H.; Thompson, M.P.; Forman, C.J.; Guo, S.; Hickman, R. J.; Parrish, K.; Aspuru-Guzik, A.; Cronin, L.; Gianneschi, N. C.; Goldsmith, R. H., 鈥淥ptical monitoring of polymerizations in droplets with high temporal dynamic range鈥, Chem. Sci., 2020, 11, 2647-2656
  4. Dobbins, D. J.; Scheutz, G. M.; Sun, H.; Crouse, C.A.; Sumerlin, B. S., 鈥淕lass Transition Temperature Governs the Thermal Decrosslinking Behavior of Diels-Alder Crosslinked Polymethacrylate Networks鈥, J. Polym. Sci., 2020, 58, 193-203.
  5. Sun, H.; Choi, W.; Zang, N.; Battistella, C.; Thompson, M. P.; Cao, W.; Zhou, X.; Forman, C.; Gianneschi, N. C., 鈥淏ioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical Polymerization鈥, Angew. Chem. Int. Ed., 2019, 58, 17359-17364 (Selected for Back cover).
  6. Sun, H.; Yang, L; Thompson, M. P; Schara, S; Cao, W; Choi, W; Hu, Z; Zang, N; Tan, W; Gianneschi, N. C., 鈥淩ecent Advances in Amphiphilic Polymer-Oligonucleotide Nanomaterials via Living/Controlled Polymerization Technologies鈥, Bioconjug. Chem., 2019, 30, 7, 1889-1904.
  7. Liu, D.; Zeng, R.; Sun, H.; Zhang, L.; Tan, J., 鈥淏lue Light-Initiated Alcoholic RAFT Dispersion Polymerization of Benzyl Methacrylate: A Detailed Study鈥, Polymers, 2019, 11(8), 1284.
  8. Touve, M. A.; Wright, D. B.; Mu, C.; Sun, H.; Park, C.; Gianneschi, N. C., 鈥淏lock Copolymer Amphiphile Phase Diagrams by High-Throughput Transmission Electron Microscopy鈥, Macromolecules, 2019, 52, 5529-5537.
  9. Fuller, E.G. 鈥; Sun, H. 鈥; Dhavalikar, R.D.; Unni, M.; Scheutz, G. M.; Sumerlin, B. S.; Rinaldi, C., 鈥淓xternally Triggered Heat and Drug Release from Magnetically Controlled Nanocarriers鈥, ACS Applied Polymer Materials, 2019, 1, 211-220. (Editor鈥檚 top pick)
  10. Sun, H.; Kabb, C. P.; Sims, M. B.; Sumerlin, B. S., 鈥淎rchitecture-Transformable Polymers: Reshaping the Future of Stimuli-Responsive Polymers鈥, Prog. Polym. Sci., 2019, 89, 61-75. (ESI highly cited paper)
  11. Tan, J.; Dai, X.; Zhang, Y.; Yu, L.; Sun, H.; Zhang, L., 鈥淧hotoinitiated polymerization-induced self-assembly via visible light-induced RAFT-mediated emulsion polymerization鈥, ACS Macro Lett, 2019, 8, 205-212. (Selected for cover; ESI highly cited paper).
  12. Yang, L.; Sun, H.; Liu, Y.; Hou, W.; Yang, Y.; Cai, R.; Cui, C.; Zhang, P.; Pan, X.; Li, X.; Li, L.; Sumerlin, B. S.; Tan, W., 鈥淪elf-Assembled Aptamer-Hyperbranched Polymer Nanocarrier for Targeted and Photoresponsive Drug Delivery鈥, Angew. Chem. Int. Ed., 2018, 57, 17048-17052.
  13. Tang, H.; Luan, Y.; Yang, L.; Sun, H.*, 鈥淎 Perspective on Reversibility in Controlled Polymerization Systems: Recent Progress and New Opportunities鈥, Molecules, 2018, 23(11), 2870. (Corresponding author).
  14. Liu, Y.; Sun, H.; Yang, L.; Liang, J.; Li, X.; Jiang, Y.; Hou, W.; Ferreira, C.; Talham, D. R.; Tan, W., 鈥淐helation-Assisted Assembly of Multidentate Colloidal Nanoparticles into Metal-Organic Nanoparticles鈥, Nanoscale, 2018, 10, 21369-21373.
  15. Yang, L.; Tang, H.; Sun, H.*, 鈥淧rogress in Photo-Responsive Polypeptide Derived Nano-Assemblies鈥, Micromachines, 2018, 9, 296. (Corresponding author).
  16. Li, X.; Figg, A.; Wang, R.; Jiang, Y.; Lyu, Y.; Sun, H.; Liu, Y.; Wang, Y.; Hou, W.; Cai, R.; Cui, C.; Li, L.; Pan, X.; Sumerlin, B. S.; Tan, W., 鈥淐ross-Linked Aptamer-Lipid Micelles for Excellent Stability and Specificity in Target Cell Recognition鈥, Angew. Chem. Int. Ed., 2018, 57, 115899-11593.
  17. Sun, H.; Kabb, C. P.; Dai, Y.; Hill, M. R.; Ghiviriga, I.; Bapat, A. P.; Sumerlin, B. S., 鈥淢acromolecular Metamorphosis via Stimulus-Induced Transformations of Polymer Architecture鈥, Nature Chemistry, 2017, 9, 817-823. (Highlighted in Chemistry World 2017, February 21st).
  18. Dai, Y.; Sun, H.; Pal, S.; Zhang, Y.; Park, S.; Kabb, C. P.; Wei, W.; Sumerlin, B. S., 鈥淣ear-IR-Induced Dissociation of Thermally-Sensitive Star Polymers鈥, Chem. Sci., 2017, 8, 1815-1821.
  19. Liu, Y.; Hou, W.; Sun, H.; Cui, C.; Zhang, L.; Jiang, Y.; Wu, Y.; Wang, Y.; Li, J.; Sumerlin, B. S.; Liu, Q.; Tan, W., 鈥淭hiol-Ene Click Chemistry: A Biocompatible Way for Orthogonal Bioconjugation of Colloidal Nanoparticles鈥, Chem. Sci., 2017, 8, 6182-6187.
  20. Wan, S.; Zhang, L.; Wang, S.; Liu, Y.; Wu, C.; Cui, C.; Sun, H.; Shi, M.; Jiang, Y.; Li, L.; Qiu, L.; Tan, W., 鈥淢olecular Recognition-Based DNA Nanoassemblies on the Surfaces of Nanosized Exosomes鈥, J. Am. Chem. Soc., 2017, 139 (15), 5289-5292. (ESI highly cited paper).
  21. Alfurhood, J. A.; Sun, H.; Kabb, C. P.; Tucker, B. S.; Matthews, J. H.; Luesch, H.; Sumerlin, B. S., 鈥淧oly(N-(2-Hydroxypropyl) Methacrylamide)-Valproic Acid Conjugates as Block Copolymer Nanocarriers鈥, Polym. Chem., 2017, 8, 4983-4987.
  22. Wang, Y.; Wu, C.; Chen, T.; Sun, H.; Cansiz, S.; Zhang, L.; Cui, C.; Hou, W.; Wu, Y.; Wan, S.; Cai, R.; Liu, Y.; Sumerlin, B. S.; Zhang, X.; Tan, W., 鈥淒NA Micelle Flares: A Study of the Basic Properties that Contribute to Enhanced Stability and Binding Affinity in Complex Biological Systems鈥, Chem. Sci., 2016, 7, 6041-6049
  23. Dong, P.; Sun, H.; Quan, D., 鈥淪ynthesis of Poly(L-lactide-co-5-amino-5-methyl-1,3-dioxan-2-ones)[P(L-LA-co-TAc)] Containing Amino Groups via Organocatalysis and Post-Polymerization Functionalization鈥, Polymer, 2016, 97, 614-622.
  24. Alfurhood, J.A.; Sun, H.; Bachler, P. R.; Sumerlin, B. S., 鈥淗yperbranched Poly(N-(2-Hydroxypropyl) Methacrylamide) via RAFT Self-Condensing Vinyl Polymerization鈥, Polym. Chem., 2016, 7, 2099-2104.
  25. Sun, H.; Dobbins, D. J.; Dai, Y.; Kabb, C. P.; Wu, S.; Alfurhood, J. A.; Rinaldi, C.; Sumerlin, B. S., 鈥淩adical Departure: Thermally-Triggered Degradation of Azo-Containing Poly(尾-Thioester)s鈥, ACS Macro lett, 2016, 5, 688-693.
  26. Tan, J.; Sun, H.; Yu, M.; Sumerlin, B. S.; Zhang, L., 鈥淧hoto-PISA: Shedding Light on Polymerization-Induced Self-Assembly鈥, ACS Macro lett, 2015, 4, 1249-1253. (ESI highly cited paper)
  27. Sun, H.; Kabb, C.P.; Sumerlin, B. S., 鈥淭hermally-Labile Segmented Hyperbranched Copolymers: Using Reversible-Covalent Chemistry to Investigate the Mechanism of Self-Condensing Vinyl Copolymerization鈥, Chem. Sci., 2014, 5, 4646-4655.
Patents
  1. Rinaldi, C.; Sun, H.; Sumerlin, B. S., 鈥淢agnetic Particle Conjugates, Micelles, and Methods of Delivering Agents鈥 PCT/US17/028852, WO2017189356A1, 2019.
  2. Gianneschi, N.C.; Lavine, J.A.; Zhang, B.; Berger, O.; Choi, W.; Wang, M.; Battistella, C.; Sun, H., 鈥淏rush Polymers for Therapeutic Applications鈥 PCT/US2020/045729, WO/2021/030326, 2020.
  3. Gianneschi, N.C.; Sun, H., 鈥淏ioactive Peptide Brush Polymers via Photoinduced Reversible-Deactivation Radical Polymerization鈥 PCT/US2020/053308, WO/2021/067293, 2020.
  4. Gianneschi, N.C.; Liang, Y.; Sun, H., 鈥淔ully and Partially Backbone-Degradable Polymers via Low Temperature Ring-Opening Metathesis Polymerization (ROMP)鈥 US Provisional 63/047,799, 2020.